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Maurizio Pellecchia Selected Research

apogossypol

5/2012Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells.
5/2011Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
5/2010BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
7/2009Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
4/2009Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
3/2008Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

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Maurizio Pellecchia Research Topics

Disease

68Neoplasms (Cancer)
06/2021 - 12/2003
18Melanoma (Melanoma, Malignant)
11/2021 - 04/2009
12Prostatic Neoplasms (Prostate Cancer)
10/2020 - 02/2006
8Neoplasm Metastasis (Metastasis)
10/2020 - 12/2012
8Leukemia
07/2018 - 09/2003
5Pancreatic Neoplasms (Pancreatic Cancer)
07/2018 - 01/2015
5Infections
11/2017 - 01/2006
5Anthrax
09/2010 - 07/2005
4Human Influenza (Influenza)
10/2015 - 07/2007
4Carcinogenesis
07/2012 - 09/2003
3Breast Neoplasms (Breast Cancer)
06/2021 - 05/2010
3Adenocarcinoma
01/2015 - 09/2010
3Lymphoma (Lymphomas)
01/2011 - 07/2005
3B-Cell Lymphoma (Lymphoma, B Cell)
11/2010 - 07/2009
2Inflammation (Inflammations)
01/2016 - 01/2006
2Glioma (Gliomas)
01/2015 - 01/2014
2Plague (Bubonic Plague)
01/2013 - 03/2005
2Carcinoma (Carcinomatosis)
06/2010 - 11/2009
1Emphysema
11/2020
1Pneumonia (Pneumonitis)
11/2020
1Chronic Obstructive Pulmonary Disease (COPD)
11/2020
1Confusion (Bewilderment)
01/2020
1Multiple Myeloma
07/2018
1Circulating Neoplastic Cells
01/2018
1Shock
11/2017
1Sepsis (Septicemia)
11/2017
1Septic Shock (Toxic Shock Syndrome)
11/2017
1Glioblastoma (Glioblastoma Multiforme)
10/2017
1Brain Neoplasms (Brain Tumor)
10/2017
1Yersinia Infections
04/2016
1Atherosclerotic Plaque (Atheroma)
04/2016
1Drug-Related Side Effects and Adverse Reactions
03/2016
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
07/2015

Drug/Important Bio-Agent (IBA)

32Proteins (Proteins, Gene)FDA Link
11/2021 - 09/2003
21Pharmaceutical PreparationsIBA
01/2018 - 03/2004
9EphA2 ReceptorIBA
10/2020 - 12/2008
9Peptides (Polypeptides)IBA
01/2018 - 07/2007
8LigandsIBA
10/2020 - 02/2006
71,1',6,6',7,7'- hexahydroxy- 3,3'- dimethyl- N5- (2- phenylpropyl)- N5'- (2- phenylpropyl)- 2,2'- binaphthyl- 5,5'- dicarboxamideIBA
06/2015 - 05/2010
6SynteninsIBA
10/2017 - 12/2012
6CytokinesIBA
03/2016 - 06/2010
6apogossypolIBA
05/2012 - 03/2008
5Paclitaxel (Taxol)FDA LinkGeneric
01/2018 - 03/2012
4Antineoplastic Agents (Antineoplastics)IBA
01/2017 - 05/2010
4InterleukinsIBA
01/2015 - 06/2010
4Phosphoric Monoester Hydrolases (Phosphatases)IBA
11/2014 - 03/2005
33- (3- (1H- benzo(d)imidazol- 2- yl)acryloyl)- 6- chloro- 4- phenylquinolin- 2(1H)- oneIBA
01/2013 - 04/2009
3PolyphenolsIBA
01/2004 - 09/2003
2Protein Isoforms (Isoforms)IBA
01/2016 - 12/2010
2ABT-737IBA
07/2015 - 05/2011
2CaspasesIBA
06/2015 - 11/2005
2Phosphotransferases (Kinase)IBA
04/2015 - 10/2011
2Hemagglutinins (Hemagglutinin)IBA
02/2015 - 07/2007
2CollagenIBA
01/2015 - 05/2012
2Matrix Metalloproteinases (MMPs)IBA
01/2015 - 05/2012
2LipidsIBA
11/2014 - 12/2008
2AD 5IBA
01/2014 - 05/2012
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
08/2013 - 12/2009
2GossypolIBA
11/2012 - 03/2008
2Proline (L-Proline)FDA Link
01/2012 - 12/2007
2Glutamic Acid (Glutamate)FDA Link
10/2011 - 11/2005
2Tyrosine (L-Tyrosine)FDA Link
10/2011 - 03/2005
2Biological ProductsIBA
10/2011 - 11/2010
2Interleukin-10 (Interleukin 10)IBA
05/2011 - 06/2010
2UbiquitinIBA
09/2010 - 12/2009
2Ligases (Synthetase)IBA
09/2010 - 12/2009
2Metalloproteases (Metalloproteinases)IBA
09/2010 - 07/2005
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2009 - 02/2006
1Lysine (L-Lysine)FDA Link
11/2021
1StreptavidinIBA
06/2021
1Indicators and Reagents (Reagents)IBA
06/2021
1Interleukin-4 (Interleukin 4)IBA
11/2020
1Pancreatic Elastase (Elastase)IBA
11/2020
1enzalutamideIBA
10/2020
1Serine Proteases (Serine Protease)IBA
01/2020
1LCL161IBA
07/2018
1ResistinIBA
11/2017
1LipopolysaccharidesIBA
11/2017
1SyndecansIBA
10/2017
1Carrier Proteins (Binding Protein)IBA
10/2017
1NucleosidesIBA
03/2016
1GemcitabineFDA Link
03/2016
1Hormones (Hormone)IBA
03/2016
1Adenosine DeaminaseIBA
01/2016
1Adenosine (Adenocard)FDA LinkGeneric
01/2016
1RNA IIBA
01/2016
1Antimicrobial PeptidesIBA
01/2016
1InosineFDA Link
01/2016
1Peptide Initiation Factors (Initiation Factor)IBA
12/2015
1SBI-0640756IBA
12/2015
1Eukaryotic Initiation Factor-4F (EIF4F)IBA
12/2015
1RNA (Ribonucleic Acid)IBA
10/2015
1navitoclaxIBA
07/2015
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
06/2015

Therapy/Procedure

34Therapeutics
11/2020 - 03/2004
10Drug Therapy (Chemotherapy)
06/2021 - 01/2004
2Chemoprevention
01/2004 - 12/2003
1Immunomodulation
11/2017
1Radiotherapy
10/2017
1Immunotherapy
03/2016